Scientific Research

Treatment options have evolved for metastatic castration-resistant prostate cancer (mCRPC). The aim of our study was to examine real-world (RW) treatment patterns and survival for individuals with mCRPC via a systematic literature review of RW observational studies.

Treatment landscapes have changed dramatically in prostate cancer in the past decade. Therapies like androgen receptor pathways inhibitors (ARPIs), which were initially approved for mCRPC are now approved in the earlier disease spectrum, including biochemical recurrence (BCR), non-metastatic castration-resistant prostate cancer (nmCRPC), and hormone-sensitive metastatic prostate cancer (mHSPC).

Hereditary angioedema (HAE) is a rare genetic disease characterized by recurrent, painful, unpredictable, and debilitating attacks of angioedema which are detrimental to patients’ quality of life. Understanding the experience of patients living with HAE and existing unmet medical needs is critical for HAE management optimization.

Systematic literature reviews (SLRs) are key evidence requirements for health technology agency decision-making. However, the exponential increase in published articles makes a thorough and practical literature review increasingly challenging. To help researchers conduct an SLR, we developed a machine learning (ML)-based pipeline to accelerate the title and abstract screening (TIABS) step. We assessed this ML-based…

Artificial intelligence (AI) model fitting by supervised learning suggests that larger training datasets tend to produce more accurate predictions. This can be demonstrated by evaluating the final tuned model on a labeled test dataset. However, it is not clear what the minimum number of records is for training such models and whether larger training datasets…